Downregulation of Bak confers resistance of MDA-MB-231 cells to Taxol.
- Yanwei Luo (800463)
- Xinye Wang (420298)
- Heran Wang (800464)
- Yang Xu (178421)
- Qiuyuan Wen (523375)
- Songqing Fan (243697)
- Ran Zhao (337603)
- Shihe Jiang (800465)
- Jing Yang (13969)
- Yukun Liu (800466)
- Xiayu Li (129691)
- Wei Xiong (58411)
- Jian Ma (170138)
- Shuping Peng (129727)
- Zhaoyang Zeng (129701)
- Xiaoling Li (129705)
- Joshua B. Phillips (800467)
- Guiyuan Li (129719)
- Ming Tan (34506)
- Ming Zhou (73279)
Publication date
September 2015
DOIAbstract
<p>(A) QPCR detection of Bak mRNA after siRNA transfection. (B) Western blot detection of the Bak expression after siRNA transfection and its quantification. (C) Downregulation of Bak inhibited Taxol induced apoptosis in MDA-MB-231 cells measured by cytometry analysis. (D) Downregulation of Bak significantly decreased the inhibition rate compared with the negative control group. (E) Western blot detection of c-PARP expression and its quantification. c-PARP, cleaved PARP. Data are expressed by means ± sd. **P<0.01, ***P<0.001 <i>vs</i> negative control.</p
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