Logistic regression of low ranked cognitive function (lowest quintile) in midlife (~50 y) on inflammatory markers at age ~30 y (baseline) or ~43 y (follow-up) and 13 y change in GlycA: the Jerusalem LRC longitudinal study.

<p>LRC, Lipid Research Clinic; CRP, C-reactive protein.</p><p>^a Box-Cox transformed CRP (λ = 0).</p><p>^b Additionally adjusted for baseline measurement of GlycA and time elapsed between measurements.</p><p>^c Compared to the 4 lowest quintiles grouped.</p><p>Model 1: Unadjusted</p><p>Model 2: Adjusted for age, sex, educational level, origin, childhood SES (ICBS ranking) and adult SES (ICBS ranking), depression, and baseline leisure-time vigorous activity, smoking status and BMI measured at ages 28–32.</p><p>Model 3: Model 2 plus change in smoking status, change in BMI, and duration between measurements. Reference level of dummy variables: sex, females; educational level, elementary (<9 yrs.); origin, Israel; leisure-time vigorous activity, none; smoking status, never; change in smoking status, no change. Age, childhood SES, adult SES, depression, BMI, change in BMI; all introduced as continuous/ interval variables.</p><p>^d Missing data: CRP (n = 14), white blood cell count (n = 12), fibrinogen (n = 43), GlycA at baseline (n = 21), GlycA change (n = 23), adult SES (n = 5), depression (n = 4), leisure-time vigorous activity (n = 1), change in BMI (n = 1). Missing values of adult SES, depression, leisure-time vigorous activity and change in BMI were replaced with non-missing median or mean values.</p><p>P-values in parentheses.</p><p>* p < .05.</p><p>** p < .01</p><p>Logistic regression of low ranked cognitive function (lowest quintile) in midlife (~50 y) on inflammatory markers at age ~30 y (baseline) or ~43 y (follow-up) and 13 y change in GlycA: the Jerusalem LRC longitudinal study.