The effect of proteases on extracellular cytokine accumulation from cultures containing M2-biased macrophages.

<p>PBMC were cultured as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138748#pone.0138748.g005" target="_blank">Fig 5</a>, and after 2 days of protease treatment, conditioned media were analyzed by ELISA for <b>(A)</b> IL-4, <b>(B)</b> IL-13, <b>(C)</b> IL-10, and <b>(D)</b> IL-12. Values are mean ± SEM, n = 6. * indicates p < .05 and ** p < .01 compared to the no-protease control (paired two-tailed t-tests).