Loss of Ticam1 signaling blocks Poly I:C induced increases in enteroid area.

<p>Enteroids and colonoids were grown from Ticam1^Lps2 jejunum and colon. <b>A)</b> Enteroids cultured in Poly I:C were assessed for buds, area and survival percentage as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138531#pone.0138531.g001" target="_blank">Fig 1</a>, n = 6 individual preparations. <b>B)</b> Colonoids were cultured in Poly I:C and assessed for buds, area and survival percentage as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138531#pone.0138531.g002" target="_blank">Fig 2</a>, n = 6. Bars represent mean ± SEM. Images were obtained at 4X, scale bars represent 100μm. Significance determined by Student’s t-test, *p<0.05.