Model assumption.

<p>(A, B) Box plots showing cell lines with similar gene expression profiles responding similarly to the same drugs. The X-axis indicates the Pearson correlation coefficients between all possible cell line pairs based on expression profiles. The Y-axis shows the correlations of their drug response vectors as measured by activity area in CCLE (A) and CGP (B). (C, D) Box plots showing that drugs with similar 1-D and 2-D structural features based on PaDEL exhibiting similar effects on cell lines in the CCLE (C) and CGP (D) datasets. The X-axis represents the drug similarity categories, and the Y-axis shows the correlations of drug responses across all cell lines. Statistical differences between two groups were measured by the t-test.