Cellular uptake of the peptide-fusion protein (TACH-MAP30-LATA) and MAP30 by cancer and normal cells.
- Hussin A. Rothan (550278)
- Jamunaa Ambikabothy (801494)
- Ammar Y. Abdulrahman (801495)
- Hirbod Bahrani (550279)
- Mojtaba Golpich (801496)
- Elham Amini (801497)
- Noorsaadah A. Rahman (738169)
- Teow Chong Teoh (738168)
- Zulqarnain Mohamed (550280)
- Rohana Yusof (401395)
Publication date
September 2015
DOIAbstract
<p><b>A)</b> Fluorescence ELISA-like cell-based assay at 0 to 2.5 μM showed the peptide-fusion protein was internalized more efficiently than MAP30 into cancer cells (HepG2 and MCF-7) compared with normal cells (WRL68 and ARPE19) in a dose-dependent manner<b>. B)</b> Confocal laser microscopy analysis showed TACH-MAP30-LATA was preferentially uptaken by HepG2 and MCF-7, compared with normal cells (WRL68 and ARPE19), whereas the cellular uptake of MAP30 was less in all cell lines.</p
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