OCT images of AOM-treated mouse colon.

<p>(a) Cross-sectional image (B-scan) showing adenoma (AD), characterized by rapid attenuation and loss of tissue boundary visibility. The horizontal axis is circumferential and the vertical axis is depth. (b) <i>En face</i> standard-deviation projection of the colon with the anus located at the top. Adenoma are bounded by dashed curves. Crypt structure can also be visualized. (c) Enlarged region denoted by the square inset in (b) showing crypts. Notice the non-uniform crypt density and crypt elongation compared to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139396#pone.0139396.g005" target="_blank">Fig 5c</a>. The colon circumference (horizontal axis in (a) and (b)) is 6.3mm and the length (vertical axis in (b)) is 15 mm. The horizontal dashed line in (b) indicates the location of the B-scan displayed in (a). All scale bars are 1mm.