Screening for hemochromatosis in asymptomatic subjects with or without a family history
- Powell, Lawrie W.
- Dixon, Jeannette L.
- Ramm, Grant A.
- Purdie, David M.
- Lincoln, Douglas J.
- Anderson, Gregory J.
- Subramaniam, V. Nathan
- Hewett, David G.
- Searle, Jeffrey W.
- Fletcher, Linda M.
- Crawford, Darrell H.
- Rodgers, Helen
- Allen, Katrina J.
- Cavanaugh, Juleen A.
- Bassett, Mark L.
Publication date
January 2006
DOI Publisher
American Medical Association (AMA)Abstract
Background: Hemochromatosis in white subjects is mostly due to homozygosity for the common C282Y substitution in HFE. Although clinical symptoms are preventable by early detection of the genetic predisposition and prophylactic treatment, population screening is not currently advocated because of the discrepancy between the common mutation prevalence and apparently lower frequency of clinical disease. This study compared screening for hemochromatosis in subjects with or without a family history
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