Overlap of lymphoma risk SNPs with regulatory regions in GM12878.

<p>The histograms represent the distribution of how many random loci overlap a specific annotation. The blue represents the mean of the empirical null distribution while the red line represents the real number of loci from the lymphoma and CLL GWAS that overlap the specific regulatory annotation. A, Overlap of SNPs with DNase hypersensitivity regions in GM12878. B, Overlap of SNPs with active promoters and strong enhancers as annotated by ChromHMM in GM12878. C, Overlap of SNPs with active promoters and strong enhancers as annotated by Segway in GM12878.