Relationship between some model parameters and the dynamic response.

<p>The basal firing rate at 33.5°C (A, D G), the maximum firing rate during the response to cold (B, E, H) and the seconds of silence after the cold pulse (C, F, I) are plotted against the TRPM8 conductance density (A-C), the ratio between depolarizing and repolarizing conductances (D-F) and the sum of the time constants involved in TRPM8 adaptation (G-I). Small black points represent the whole set of 360 parameter sets obtained and the large blue dots correspond to parameter sets listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139314#pone.0139314.t001" target="_blank">Table 1</a>.