Fatty acid biosynthesis gene locus in <i>Streptococcus pneumoniae</i>.

<p><b>(A)</b> FAS involves 13 genes that are arranged in a single locus that initiate fatty acid synthesis and product elongation. The fatty acid synthesis genes include: <i>acpP</i>, encoding acyl carrier protein (ACP); <i>accD</i>, encoding acetyl coenzyme A (acetyl-CoA) carboxylase subunit beta; <i>fabG</i>, encoding 3-ketoacyl-ACP reductase; <i>fabH</i>, encoding 3-oxoacyl-ACP synthase III; <i>fabK</i>, encoding trans-2-enoyl-ACP reductase II; <i>fabD</i>, encoding ACP S-malonyltransferase; <i>fabF</i>, encoding 3-oxoacyl-ACP synthase II; fabZ, encoding (3R)-hydroxymyristoyl-ACP dehydratase; accA, encoding acetyl coenzyme A (acetyl-CoA) carboxylase subunit alph; accB, encoding acetyl coenzyme A (acetyl-CoA) carboxylase subunit; and accC, encoding acetyl coenzyme A (acetyl-CoA) carboxylase subunit. (B) The interconnection of fatty acid genes detected by STRING v9.1 on the basis of terms on the right. The fold-changes in gene expression are highlighted.