<p>Note: Group A: negative female controls without CTx treatment; Group B: female mice administered nonlethal doses of CTx (busulfan 30 mg/kg, cyclophosphamide 120 mg/kg) without transplantation of FGSCs; Group C: female mice administered the same dose of CTx as Group B, with the transplantation of FGSCs one week after the CTx; Group D: female mice administered the same dose of CTx as Group B, with the transplantation of FGSCs two months after the CTx; Group E:female mice administered median lethal doses (LD50) of CTx (busulfan 20 mg/kg, cyclophosphamide 200 mg/kg), without the transplantation of FGSCs; Group F: female mice administered the same dose of CTx as Group E, with the transplantation of FGSCs one week after the CTx. I: the offspri...
The purpose of the study was a comparative experimental assessment of long-term toxic effects of cyt...
textabstractThe aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI)...
<p>(A) Pregnancy rate in the control (open squares: <i>Gcg<sup>+/+</sup></i> and <i>Gcg<sup>gfp/+</s...
<p>Note: Group 1A: six normal female mice without any treatment; Group 1B: six female mice were admi...
<p>(A) The number of estrous cycles in two weeks was evaluated in the mice. Con = Non-CTx-mice (n ...
Diethylstilbestrol (DES) was selected as a positive control compound to study a new assay for reprod...
<p>Abbreviation: ND, no data.</p>a<p>Values given as absolute number and percentage of total vaginal...
<p>(<b>A</b>) Weekly comparison of the cumulative number of pups for the low dose bpV(HOpic)-injecte...
Summary. Groups of twenty female QS-strain mice were injected with a single dose of 0, 1, 3 or 9 mg ...
The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibit...
sessment by Continuous Breeding (RACB) bioassays were used to directly compare differential ovarian ...
<p>Four males per dose mated five females each to give a total of twenty dams per dose. Ten of these...
<p>Six-week-old female mice received [<i>per os</i>, once daily (5d/wk)] either sunitinib (n = 19) o...
<p>The information of offspring produced by mice in each group after busulfan treatment.</p
<p>(A) body weight of female mice, (B) body weight of male mice, (C) fertility of female mice, (D) F...
The purpose of the study was a comparative experimental assessment of long-term toxic effects of cyt...
textabstractThe aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI)...
<p>(A) Pregnancy rate in the control (open squares: <i>Gcg<sup>+/+</sup></i> and <i>Gcg<sup>gfp/+</s...
<p>Note: Group 1A: six normal female mice without any treatment; Group 1B: six female mice were admi...
<p>(A) The number of estrous cycles in two weeks was evaluated in the mice. Con = Non-CTx-mice (n ...
Diethylstilbestrol (DES) was selected as a positive control compound to study a new assay for reprod...
<p>Abbreviation: ND, no data.</p>a<p>Values given as absolute number and percentage of total vaginal...
<p>(<b>A</b>) Weekly comparison of the cumulative number of pups for the low dose bpV(HOpic)-injecte...
Summary. Groups of twenty female QS-strain mice were injected with a single dose of 0, 1, 3 or 9 mg ...
The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibit...
sessment by Continuous Breeding (RACB) bioassays were used to directly compare differential ovarian ...
<p>Four males per dose mated five females each to give a total of twenty dams per dose. Ten of these...
<p>Six-week-old female mice received [<i>per os</i>, once daily (5d/wk)] either sunitinib (n = 19) o...
<p>The information of offspring produced by mice in each group after busulfan treatment.</p
<p>(A) body weight of female mice, (B) body weight of male mice, (C) fertility of female mice, (D) F...
The purpose of the study was a comparative experimental assessment of long-term toxic effects of cyt...
textabstractThe aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI)...
<p>(A) Pregnancy rate in the control (open squares: <i>Gcg<sup>+/+</sup></i> and <i>Gcg<sup>gfp/+</s...