Regulation of cell adhesion to poly(ethylene glycol) diacrylate film by modification with polystyrene nano-spheres

Poly(ethylene glycol) diacrylate (PEGDA) are being investigated for various tissue engineering applications for its biocompatibility and excellent mechanical properties. However, the native PEGDA films can hinder cell adhesion which limits applications in the field of tissue engineering and biomedicine. Recently, nano composite technology has been a particularly hot topic because of it can be used to modify deliver to the materials properties. In this paper, we have added polystyrene nano-spheres into the PEGDA solution to synthesize nanocomposites film. The experimental results show that the adhesion of cell on PEGDA film can be regulated by the concentration of polystyrene nano-spheres. The cell adhesion and spread can be improved through increasing concentration of polystyrene nano-spheres. Furthermore, we find that the spheres can also change the mechanical properties of PEGDA films and further affect the cell growth status