Mean metabolite component levels stratified by the healthy control and NAFLD groups (MIXED model estimated marginal means with 95% confidence intervals are given taking into account shared environment within family, and contrast estimates’ p-values were used to localize the significant differences between the two groups and group by gender interaction).

<p>NAFLD = non-alcohol fatty liver disease; values are given as mean and 95% confident interval (CI). Factor 1 (Omega 7 and 9 and saturated fatty acids, total fatty acids, mono-unsaturated fatty acids); Factor 2 (isoleucine, leucine, valine, phenylalanine, tyrosine and orosomucoid); Factor 3 (acetate, alanine, lactate, pyruvate); Factor 4 (esterified cholesterol, free cholesterol, omega 6 fatty acids, phosphoglycerides, phosphocholines and sphingomyelines); Factor 5 (beta-hydroxybutyrate, citrate, histidine); Factor 6 (acetoacetate, glutamine)</p><p>Mean metabolite component levels stratified by the healthy control and NAFLD groups (MIXED model estimated marginal means with 95% confidence intervals are given taking into account shared environment within family, and contrast estimates’ p-values were used to localize the significant differences between the two groups and group by gender interaction).