IFN-β modulates the expression of NK cell activating ligand-receptor systems in GIC.

<p>The levels of MICA, MICB, ULBP1, ULBP2 and ULBP3 (A) and of nectin-2 and PVR (B) were assessed by flow cytometry following treatment with IFN-β (300 U/ml, 24 h). C. The levels of NKG2D and DNAM–1 on NKL cells were assessed following treatment with IFN-β (300 U/ml, 24 h) by flow cytometry (note an almost complete overlay of the flow cytometry curves of treated and untreated cells). Flow cytometry data represent mean SFI values ± SD from 3 independent experiments (SFI = 1 is marked with a dotted line) (** p<0.01, * p<0.05; student`s two tailed t-test).