Additional file 4: Figure S4. of Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats

Aging increases the frequency of CD11b + cells with monocyte/macrophage physical characteristics in peripheral blood from rats immunized for EAE. (Panel A) Flow cytometry dot plots indicate peripheral blood CD11b + monocyte/macrophage gating strategy. Flow cytometry dot plot indicates (right) CD11b expression on monocytes/macrophages gated according to FSC and SSC as shown in (left) flow cytometry dot plot. (B) Bar graph shows percentage of CD11b + monocytes/macrophages within peripheral blood cells from young and aged rats injected with CFA and Bordetella pertussis (Adjuvant) or immunized for EAE (Immunized). All results are presented as means ± SEM (n = 9/group). Data are representative of one of two experiments with similar results. ***p < 0.001. (TIFF 1294 kb