Additional file 3: of Clocks do not tick in unison: isolation of Clock and vrille shed new light on the clockwork model of the sand fly Lutzomyia longipalpis

Multiple sequence alignment of CLK orthologues in L. longipalpis [GenBank: KR706373], Ae. aegypti [GenBank:XP_001662706], An. gambiae [GenBank:XP_315720], D. melanogaster [GenBank:AAF50516], M. domestica [GenBank:XP_005180856], R. prolixus [VectorBase:RPRC002110], D. plexippus [GenBank:EHJ69324], A. pernyi [GenBank:AAR14936] and T. castaneum [GenBank:NP_001106937]. The Highlighted regions correspond to the functional domains bHLH (green), PAS (yellow) and poly-Q (purple). Note that PAS spans subunits A and B, both highly conserved in insects. The poly-Q, on the contrary, is very diversed in position and length. Text colors correlate to conservation thresholds for a position. In red font, highly conserved residues (threshold=90 %). In blue font, weakly conserved residues (threshold=50 %). (PDF 195 kb