Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins - Fig 2

<p>Body weight (g) responses during the experimental weeks for the experimental groups (A); Percentage alteration (%) of body weight between week 0 and week 8 for the experimental groups (B); Food intake (g) responses during the experimental weeks for the experimental groups (C); Percentage alteration (%) of food intake between week 0 and week 8 for the experimental groups (D); The area under curve (AUC; mg.dL⁻¹ × min) for the blood glucose responses during 120min after an intraperitoneal injection of glucose (2g.kg⁻¹) (E); The area under curve (AUC; mg.dL⁻¹ × min) for the blood glucose responses during 30min after an intraperitoneal injection of insulin (1.5 U.kg⁻¹) (F). The area under curve (AUC; mg.dL⁻¹ × min) for the blood glucose responses during 120min after an intraperitoneal injection of pyruvate (2g.kg⁻¹) (G). Data correspond to means ± SE of n = 12 mice. CT: sedentary mice; OTR/down: overtrained by downhill running; OTR/up: overtrained by uphill running; OTR: overtrained by running without inclination. GTT: glucose tolerance test; ITT: insulin tolerance test. PTT: pyruvate tolerance test. *P < 0.05 vs. CT.