LTB₄-mediated increased production of inflammatory mediators is abrogated in IAV-infected NOD2^-/- and IPS–1^-/- mice.

<p>WT, NOD2^-/- and IPS–1^-/- mice (n = 6 per group) were infected with IAV (50 PFU, i.n.) and treated (i.v.) daily with placebo or LTB₄ (1 μg/kg). Mice were sacrificed 6 hours post-treatment and levels of <b>(A, D)</b> IFNβ, <b>(B, E)</b> TNFα and <b>(C, F)</b> IL–6 were determined in lung homogenates by ELISA. Data are representative of three independent experiments. *p<0.05 as compared to indicated groups.