HBPDS has a wide neuroprotective time-window in EAE mice.

<p><b>(A-B)</b> Pre-, onset-, and post-treatment but not peak-treatment with HBPDS (30% ethanol extracted) alleviated neurological impairment in EAE mice. Sum of behavioral score indicates the sum of scores of after pre-, onset-, post-, and peak-treatment with HBPDS (30% ethanol extracted) (B). Data are expressed as mean scores ± SEM. (Two-tailed Student’s t-test; *p < 0.05 compared to EAE mice).