Loss of Smad4 Modulates Anxiety-Related Behavior in the Elevated Plus Maze.

<p>In the Elevated Plus Maze (A) the fbΔSmad4 mutant mice (blue) spent a significantly increased proportion of time exploring the open-arms, (B) had a significantly increased duration of time on the open-arms, (C) and made significantly more entries onto the open-arms compared to control littermates (white). When closed-arm exploration was examined, (D) the fbΔSmad4 mutant mice spent a significantly reduced proportion of time on the closed-arms, but (E) there was no significant difference in duration of time on the closed-arms, however, (F) the number of closed-arm entries was significantly reduced. Results reported as mean ± S.E.M. Asterisk indicates *p<0.05.