Selection of <i>S</i>. <i>mansoni</i> PZQ-resistant strain.

<p>This selection was carried out under continuous PZQ increased pressure using CD1 mice over several passages. 1—Transcutaneous infection of mice with ~100 cercariae; 2 –Oral administration of PZQ after infection confirmation by the presence of eggs in the faeces (± 60 dpi); 3 –Mice were euthanized to collect adult worms and miracidia (eggs in faeces) (± 75 dpi); 4—<i>B</i>. <i>glabrata</i> snails were infected with miracidia released from eggs; 5—Cercariae were released from snails (± 45 dpi).