Gene expression fold change profiling of RP genes during human and mouse erythropoiesis in relation to GATA1 occupancy.

<p>(A) Gene expression fold change profiling of RP genes during sequential stages of human erythroid terminal differentiation with GATA1 occupancy in fetal and adult derived erythroid cells. (B) Gene expression fold change profiling of RP genes during sequential stages of mouse erythroid terminal differentiation and GATA1 occupancy in early (Ter119-) and late (Ter119+) differentiating mouse fetal liver cells. (C) Box plots of RP gene expression fold change comparing human and mouse differential expression in sequential erythroid differentiation stages, showing an overall steep decline in RP gene expression in early stages of mouse erythroid differentiation compared to human. The different stages of human and mouse erythroid differentiation were FACS purified and subjected to RNAseq as described in An et al.[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140077#pone.0140077.ref034" target="_blank">34</a>].