MAP1B is highly expressed in kidney podocytes.

<p>Immunofluorescence staining of kidney sections derived from adult human and rat kidney. WT1 served as a marker for podocyte nuclei. Nephrin and synaptopodin served as foot process markers. DAPI was used for staining nuclei. MAP1B is expressed highly specific in podocytes (scale for overview: 50 μm; higher magnification: 25 μm) (A,C). Expression of MAP1B during glomerulogenesis in newborn rat kidney. Glomerular differentiation advances from cortex to medulla (upper right: immature; lower left: mature) (scale for overview: 50 μm; higher magnification: 25 μm) (B). Transmission electron microscopy of kidney sections. Immunolabeling of MAP1B confirms an enrichment in areas with a dense MT cytoskeleton in primary processes and the cell body (primary processes (PP), foot processes (arrowheads), Nucleus (Nu)), glomerular basement membrane (GBM); scale: 200 nm) (D).