Phenotypic traits of <i>Wrn</i>^{<i>Δhel/Δhel</i>} and <i>Wrn</i>^<i>-/-</i> mice.

<p>(A) Percentage of disease-free animals with age. The number of animals in each group is indicated (50% males + 50% females). (Log rank tests: WT <i>vs</i>. <i>Wrn</i>^{<i>Δhel/Δhel</i>} mice, <i>P</i> = 6.8x10^-5; WT <i>vs</i>. <i>Wrn</i>^<i>-/-</i> mice, <i>P</i> = 0.001; <i>Wrn</i>^{<i>Δhel/Δhel</i>}<i>vs</i>. <i>Wrn</i>^<i>-/-</i> mice, <i>P</i> = 0.955). (B) Measures of males total body weight from the age of 4 to 52 weeks (n = 6–19 males). (C) Total body weight at four months of age (n = 6–10 males). (D) Ratio of spleen wet weight over total body weight at four months of age (n = 6 males). (E) Lymphocyte blood count at four months of age (n = 5 males). (F) Platelet blood count at four months of age (n = 5 males). (G) Red blood cell count at four months of age (n = 5 males). (H) % hematocrit at four months of age (n = 5 males). Bars in all the graphs represent SEM.