Significant Target Gene Changes in Tendon with Chronic Exercise.

<p>Changes in collagen type I and III expression, decorin, and matrix turnover enzymes <i>Mmp14</i>, <i>Timp1</i>, and <i>Timp3</i> indicate an adaptive matrix response in the supraspinatus tendon to non-injurious, chronic exercise. Compared to 8 weeks of chronic exercise, more gene changes are seen at 1 week, suggesting that these adaptive processes begin soon after initiating an exercise protocol. The only altered inflammatory gene (AA pathway or cytokine) was <i>Alox5ap</i>, indicating that inflammation associated with the arachidonic acid cascade is not a main pathway in the chronic response of tendon to exercise. Mean ± Standard Deviation.