New barbiturates and thiobarbiturates as potential enzyme inhibitors

<div><p></p><p>A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87–96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for <i>in vitro antioxidant</i> (DPPH radical scavenging), <i>lipoxygenase, chymotrypsin</i>, α-<i>glucosidase</i> and <i>anti-urease</i> activities. Out of the series, 23 in <i>DPPH</i>, 14 in <i>lipoxygenase</i>, 2 in <i>chymotrypsin</i> have shown appreciable IC₅₀ values.</p>