<p><sup><i>a</i></sup> Concentrations shown represented clinically achievable unbound serum concentrations for all listed antibiotics at the corresponding doses stated except tigecycline.</p><p><sup><i>b</i></sup> Concentration shown represented average tissue concentration at the corresponding dose stated.</p><p>Simulated antibiotic dosing regimens and corresponding drug concentrations.</p
Antimicrobial efficacy in vivo is not exclusively defined by the activity of an antibiotic as determ...
<p>Values are given as median and range. Plasma levels of enrofloxacin, its active metabolite ciprof...
Pharmacodynamics is classically described as the effect of drugs on the body, which for most drugs r...
A model for in-vitro simultaneous simulation of two different patterns of pharmacokinetic parameters...
<p>Simulations were based on the true parameter values (solid black lines) or parameter values estim...
The importance of closely observing patients receiving antibiotic therapy, performing therapeutic dr...
Once-daily dosage of aminoglycosides is currently under consideration. The lower toxicity of this re...
De-escalation of empirical antibiotic therapy is often included in antimicrobial stewardship program...
Designing antibiotic dosing regimens is often not optimal and the dose-response relationship for mos...
Actual (a-5 and a-7) and simulated (s5 –s10) gentamicin peak concentrations in n (%).</p
a-5: actual given dose 5 mg/kg (phase 1); a-7: actual given dose 7 mg/kg (phase 3); s-5 –s-7: simula...
Methods that may be used to design rational dosage schedules of antimicrobial agents are reviewed. M...
Nearly all m-vitro kinetic models hitherto employed only consider serum concentration curves of the ...
<p>These graphs show results of numerical simulations of Eq (<a href="http://www.ploscompbiol.org/ar...
<p>Antimicrobial agents and dosages utilized in the main trial. Equivalent dosages in mice and human...
Antimicrobial efficacy in vivo is not exclusively defined by the activity of an antibiotic as determ...
<p>Values are given as median and range. Plasma levels of enrofloxacin, its active metabolite ciprof...
Pharmacodynamics is classically described as the effect of drugs on the body, which for most drugs r...
A model for in-vitro simultaneous simulation of two different patterns of pharmacokinetic parameters...
<p>Simulations were based on the true parameter values (solid black lines) or parameter values estim...
The importance of closely observing patients receiving antibiotic therapy, performing therapeutic dr...
Once-daily dosage of aminoglycosides is currently under consideration. The lower toxicity of this re...
De-escalation of empirical antibiotic therapy is often included in antimicrobial stewardship program...
Designing antibiotic dosing regimens is often not optimal and the dose-response relationship for mos...
Actual (a-5 and a-7) and simulated (s5 –s10) gentamicin peak concentrations in n (%).</p
a-5: actual given dose 5 mg/kg (phase 1); a-7: actual given dose 7 mg/kg (phase 3); s-5 –s-7: simula...
Methods that may be used to design rational dosage schedules of antimicrobial agents are reviewed. M...
Nearly all m-vitro kinetic models hitherto employed only consider serum concentration curves of the ...
<p>These graphs show results of numerical simulations of Eq (<a href="http://www.ploscompbiol.org/ar...
<p>Antimicrobial agents and dosages utilized in the main trial. Equivalent dosages in mice and human...
Antimicrobial efficacy in vivo is not exclusively defined by the activity of an antibiotic as determ...
<p>Values are given as median and range. Plasma levels of enrofloxacin, its active metabolite ciprof...
Pharmacodynamics is classically described as the effect of drugs on the body, which for most drugs r...