Anatomical localization of significant differences in DTI and TDI measurements between UCPPS patients (<i>N = 45</i>) and positive control patients with IBS (<i>N = 39</i>).

<p>A) Observed differences in mean diffusivity (MD). B) Observed differences in fractional anisotropy (FA). C) Observed differences in fiber track density. D) Observed differences in generalized anisotropy (GA). Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis. Left column illustrates differences projected onto representative white matter fiber tracts.