Dendritic and somatic Input Resistances determine NMDA-spike properties in realistic neuronal morphologies.

<p>A,B, The correlation between the number of synapses required for a global NMDA-spike generation in the basal dendrites and the inverse of somatic input resistance (A), soma size (B, grey) and the cumulative length of the dendritic trees (B, black) for the cortical cellular morphologies. Here and in the next plots the solid line indicates a linear fit to the data. C, D, A good correlation was found between the number of synapses required for focal NMDA-spike generation to the inverse of the focal dendritic input resistance(C) but not to the length of the stimulated branch (D), both in basal (black) and apical (grey) dendrites. E, F, A high correlation was found between somatic amplitude of the focal NMDA to the ratio between the somatic and dendritic input resistances (E) but not to the length of the stimulated branch.