Cluster analysis of detected proteins in the urine comparing patients with NMO/NMO-SD, MS and healthy subjects.

<p>(A) Out of the 1112 proteins detected in the urine, 333 proteins were found in all samples. (B) PCA of all 333 proteins differentiated NMO/NMO-SD from HS samples. (C) MS samples could not be differentiated from HS by PCA. (D) NMO/NMO-SD samples could not be differentiated from MS samples by PCA. (E) PCA of proteins, which were differentially expressed (<i>p</i><0.05) compared to HS and present in at least 80% of the samples enabled differentiation of the NMO/NMO-SD samples from HS. (F) PCA of proteins, which were differentially expressed (<i>p</i><0.05) compared to HS and present in at least 80% of the samples enabled separation of the MS samples from HS. (G) PCA of proteins, which were differentially expressed (<i>p</i><0.05) compared to HS and present in at least 80% of the samples enabled separation of the NMO/NMO-SD samples from MS. <i>PCA</i>, <i>principal component analysis; NMO/NMO-SD</i>, <i>neuromyelitis optica/neuromyelitis optica spectrum disorder; MS</i>, <i>multiple sclerosis; HS</i>, <i>healthy subjects</i>.