Three-pos by Euroline ANA profile (IgG) was a marker for severe nephropathy in LN patients.

<p><b>(A)</b> Power of anti-dsDNA, -nucleosome and–histone Abs to differentiate active LN from inactive LN accessed by ROC curve. <b>(B)</b> Three-pos was the best marker for severe nephropathy. The relevant laboratory parameters on nephropathy includes increased Scr (≥ 133μmol/L), urinary protein (≥ 3.5g/24h) and urinary RBC (≥ 3/HP). 2A, 2B and 2C respectively indicated varied 2-pos by Euroline ANA profile (IgG) in LN patients; 2A: anti-dsDNA and -nucleosome; 2B: anti-dsDNA and -histone; 2C: anti-nucleosome and -histone.