Reduced level of overall immunosuppression correlates with acute rejection events.

<p>ABS levels are shown for two individuals with (C and D) and two individuals without (A and B) moderate-to-severe acute rejection events (top). Colors indicate isotype contribution. cfdDNA levels are shown for the same individuals (bottom). Biopsy grades are shown as vertical blue lines (bottom). Thin lines indicate mild ACR events (grade 1R), and thick lines indicate moderate-to-severe ACR events (grade ≥ 2R).