Additional file 5: Figure S4. of Multipotent luminal mammary cancer stem cells model tumor heterogeneity

Validation of expression array data by GSEA and RT-PCR. A. Gene set for mammary luminal progenitor cells is significantly enriched (P <0.001) in luminal versus claudin-low tumors. B. Gene set for mammary stem cells is not enriched in luminal versus claudin-low tumors. C. Genes downregulated in mammary stem cells are significantly enriched (P <0.01) in the Py230 luminal cell line compared with the Py16-1 claudin-low cell line. D. Confirmation of lower expression of several mammary luminal progenitor-associated genes in Py16-1, a claudin-low cell line compared with the parental Py230 cell line. E. Confirmation of higher expression of several mammary stem cell-associated genes in Py16-1, a claudin-low cell line compared with the parental Py230 cell line. F. Higher expression of genes downregulated in mammary stem cells in luminal Py230 cell line compared with claudin-low Py16-1. For each gene comparison *P <0.05, ***P <0.005, ****P