<p>SMN2 mRNA was isolated from blood and analyzed using qRT-PCR. Expression level is calculated using 2ˆ-deltaCp of the reference gene. There is a strong overlap of SMN2 mRNA in the different patient groups. Note that in the healthy controls SMN2 levels are lower than levels in patients with the same SMN2 copy number.</p
<p>(<b>A</b>) Immunoblot of SMN and β-actin following knockdown of SRSF3 with siRNA in SMA patient-d...
<p>While SMN protein levels are lower in SMA relative to Control subjects, protein levels by SMA typ...
<p>Representative immunoblots of both differentiated and undifferentiated mESCs revealed a significa...
<p>(A) SMN2 mRNA expression levels in blood from patients with SMA. SMN2-Δ7 levels were significantl...
<p>A,C: SMN2-FL, SMN-FL and Total SMN transcripts generally increase with SMA Type. SMN-FL (A) is a ...
<p>Significant correlation between expression levels of SMN protein and SMN2 mRNA in Type 1 and Type...
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a...
<p>(A) SMN levels with respect to age in all subjects. (B) SMN protein levels were measured in SMA p...
<div><p>Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which le...
Molecular analysis of the two hESC unaffected and the two hESC SMA Type 1 lines revealed no SMN1 exp...
The universal presence of a gene (SMN2) nearly identical to the mutated SMN1 gene responsible for Sp...
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a...
<p>The “SMN2 copy number” and “SMN-FL transcript” columns include the partial correlation analysis f...
BACKGROUND: Clinical trials to test safety and efficacy of drugs for patients with spinal muscular a...
<p>Mean SMN protein levels are higher in controls compared to patients. SMN protein levels in PBMCs ...
<p>(<b>A</b>) Immunoblot of SMN and β-actin following knockdown of SRSF3 with siRNA in SMA patient-d...
<p>While SMN protein levels are lower in SMA relative to Control subjects, protein levels by SMA typ...
<p>Representative immunoblots of both differentiated and undifferentiated mESCs revealed a significa...
<p>(A) SMN2 mRNA expression levels in blood from patients with SMA. SMN2-Δ7 levels were significantl...
<p>A,C: SMN2-FL, SMN-FL and Total SMN transcripts generally increase with SMA Type. SMN-FL (A) is a ...
<p>Significant correlation between expression levels of SMN protein and SMN2 mRNA in Type 1 and Type...
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a...
<p>(A) SMN levels with respect to age in all subjects. (B) SMN protein levels were measured in SMA p...
<div><p>Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which le...
Molecular analysis of the two hESC unaffected and the two hESC SMA Type 1 lines revealed no SMN1 exp...
The universal presence of a gene (SMN2) nearly identical to the mutated SMN1 gene responsible for Sp...
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a...
<p>The “SMN2 copy number” and “SMN-FL transcript” columns include the partial correlation analysis f...
BACKGROUND: Clinical trials to test safety and efficacy of drugs for patients with spinal muscular a...
<p>Mean SMN protein levels are higher in controls compared to patients. SMN protein levels in PBMCs ...
<p>(<b>A</b>) Immunoblot of SMN and β-actin following knockdown of SRSF3 with siRNA in SMA patient-d...
<p>While SMN protein levels are lower in SMA relative to Control subjects, protein levels by SMA typ...
<p>Representative immunoblots of both differentiated and undifferentiated mESCs revealed a significa...