Overview of the algorithm for predicting PD DDIs.

<p>The signaling propagation starting from drug targets (Drug_A: Protein 2 and Drug_B: Protein 4) through the PPI network is simulated by RWR algorithm. The <i>ProteinScore</i> is defined as the values of the protein profile of drug pairs after finishing the simulation of RWR algorithm. The <i>DDIScore</i> is calculated by the summation of the <i>ProteinScore</i> of all proteins. The <i>DDIScore</i> represents the interference of signaling propagation through PPI network between drugs.