<p>Wild type C9 cells (panel A) or overexpressing LPA<sub>1</sub> (panel B), LPA<sub>2</sub> (panel C) or LPA<sub>3</sub> (panel D) were stimulated by different concentrations of LPA. Plotted are the increases in intracellular calcium as mean ± S. E. M. of 4–5 experiments using different cell preparations.</p
<p>(A) Average current densities of I<sub>Ca,L</sub> in the absence and presence of LPA (10 µM). The...
<p>A: LA-stimulated increase in [Ca<sup>2+</sup>]i in U73122 treatment (10µM for 10min). B: the stat...
<p>A: blank control. B: Increase in [Ca<sup>2+</sup>]i induced by 2 min LA treatment. C: Increase in...
<p>Cells overexpressing LPA<sub>1</sub> (black, circles), LPA<sub>2</sub> (blue, squares) or LPA<sub...
<p>Cells overexpressing LPA<sub>1</sub> (panel A, black symbols and lines), LPA<sub>2</sub> (panel B...
<p>Cells overexpressing LPA<sub>1</sub> (panel A, black), LPA<sub>2</sub> (panel B, blue) or LPA<sub...
<p>(A) Calcium flux in response to the indicated concentrations of LPA in control (grey tracing) or ...
<p>Cells overexpressing LPA<sub>1–3</sub> receptors were preincubated overnight with 1 μM PMA, and t...
<p>Cells were loaded with Fura 2-AM. At the time of the experiment 100 µM EGTA was added 30 sec befo...
<p>Cells were pre-treated with IS for 1 h and then co-treated with LPS and IS (1000–62.5 µM) for 15 ...
<p>Cells overexpressing LPA<sub>1–3</sub> receptors were preincubated for 15 min in the presence of ...
<p>A–C: Increase in [Ca<sup>2+</sup>]i in rat β-cells induced by GW9508, 2-min LA and 10-min LA, res...
<p>(A) Representative intracellular paired pulse Ca<sup>2+</sup> recordings and grouped data of the ...
<p>Cells overexpressing LPA<sub>1</sub> (panel A), LPA<sub>2</sub> (panel B) or LPA<sub>3</sub> (Pan...
<p>Cells overexpressing LPA<sub>1</sub> (panel A), LPA<sub>2</sub> (panel B) or LPA<sub>3</sub> (Pan...
<p>(A) Average current densities of I<sub>Ca,L</sub> in the absence and presence of LPA (10 µM). The...
<p>A: LA-stimulated increase in [Ca<sup>2+</sup>]i in U73122 treatment (10µM for 10min). B: the stat...
<p>A: blank control. B: Increase in [Ca<sup>2+</sup>]i induced by 2 min LA treatment. C: Increase in...
<p>Cells overexpressing LPA<sub>1</sub> (black, circles), LPA<sub>2</sub> (blue, squares) or LPA<sub...
<p>Cells overexpressing LPA<sub>1</sub> (panel A, black symbols and lines), LPA<sub>2</sub> (panel B...
<p>Cells overexpressing LPA<sub>1</sub> (panel A, black), LPA<sub>2</sub> (panel B, blue) or LPA<sub...
<p>(A) Calcium flux in response to the indicated concentrations of LPA in control (grey tracing) or ...
<p>Cells overexpressing LPA<sub>1–3</sub> receptors were preincubated overnight with 1 μM PMA, and t...
<p>Cells were loaded with Fura 2-AM. At the time of the experiment 100 µM EGTA was added 30 sec befo...
<p>Cells were pre-treated with IS for 1 h and then co-treated with LPS and IS (1000–62.5 µM) for 15 ...
<p>Cells overexpressing LPA<sub>1–3</sub> receptors were preincubated for 15 min in the presence of ...
<p>A–C: Increase in [Ca<sup>2+</sup>]i in rat β-cells induced by GW9508, 2-min LA and 10-min LA, res...
<p>(A) Representative intracellular paired pulse Ca<sup>2+</sup> recordings and grouped data of the ...
<p>Cells overexpressing LPA<sub>1</sub> (panel A), LPA<sub>2</sub> (panel B) or LPA<sub>3</sub> (Pan...
<p>Cells overexpressing LPA<sub>1</sub> (panel A), LPA<sub>2</sub> (panel B) or LPA<sub>3</sub> (Pan...
<p>(A) Average current densities of I<sub>Ca,L</sub> in the absence and presence of LPA (10 µM). The...
<p>A: LA-stimulated increase in [Ca<sup>2+</sup>]i in U73122 treatment (10µM for 10min). B: the stat...
<p>A: blank control. B: Increase in [Ca<sup>2+</sup>]i induced by 2 min LA treatment. C: Increase in...