X-ray crystallographic structure of <i>S</i>. <i>suis</i> LuxS.

<p>(A) The overall structure of the LuxS. Four LuxS monomers are in one asymmetry unit, the different color coding represents different monomers. Zn is represented as a large sphere. (B) The structural comparisons of <i>S</i>. <i>suis</i> LuxS with four known structures of LuxS. The four known structures of LuxS proteins are sampled from Protein Data Bank. The different color coding as the LuxS structure of <i>Heamophilus influenzae</i> (1JOE, yellow),<i>Deinococcus radiodurans</i> (1VH2, green), <i>Helicobacter subtilis</i> (1J6X, cyan), <i>Bacillus subtilis</i> (2FQO, grey). (C) Residue phe80 and his87 were shown, the Met and Tyr were from 1JOE and 1J6X. HYI was compound (2S)-2-amino-4-[(2R,3R)-2,3-dihydroxy-3-N-hydroxycarbamoyl-propylmercapto]butyric acid from structure 2FQO. Four structures were shown, including 1VH2 (green), 1JOE (yellow), 1J6X (cyan) and 2FQO (grey).