Whole genome sequencing of endpoint clonal isolates illustrated a wide range of mutations.

<p>(A) Total number of mutations in each clone. The two non-hypermutators (T2_F9 and T2_H3) appear on the far left of the plot with <10 mutations while T1_H11 and T1_B5 each had 395 or 415 mutations. (B) Types of mutations for the collection of 38 isolates. (C) Locations of the mutations in the AB210M genome (Trials 1, red; Trial 2, blue).