<i>A potential involvement of PPAR</i>γ <i>in apoptosis induced by combination of rosiglitazone and LA-12</i>.

<p>(a) Cleavage of caspase-9, caspase-3, PARP (Western blotting), and (b) caspase-3 activation (flow cytometry) in HCT116 wt cells transfected (24 h) with control or PPARγ siRNA, treated (24 h) with rosiglitazone (RGZ, 50 μM) and subsequently incubated (48 h) with LA-12 (0.75 μM). Results are means + S.E.M. of three independent experiments. Statistical significance: P < 0.05, * versus control, ‡ versus RGZ, Ο versus LA-12.