HIV-1 infected patients (CD4+ T-cell counts<250) have lower frequency of mDCs.

<p>(a) A representative picture showing strategy for gating mDCs in a healthy control subject wherein total leucocytes were gated for selection of DCs (Lineage-ve, HLA-DR+ve) for onward selection of myeloid DC cluster (CD11c+ve and HLA-DR+ve). (b) The percentage of mDCs were significantly lower in ART-naïve patients, CD4+ T-cell counts<250 cells/μL (n = 23) as compared to patients with CD4+ T-cell counts>250 cells/μL (n = 33) and HCs (n = 24) (p<0.05). (c) The absolute count of mDCs (cells/μL) was also sigificantly lower in ART-naïve patients, CD4+ T-cell counts<250 cells/μL as compared to patients with CD4+ T-cell counts>250 cells/μL and HCs (KW: p<0.05). Statistical analysis was performed using Kruskall-Wallis (KW) test for comparisons between multiple groups with pairwise comparisons using Dunn's multiple comparison adjustment for an overall p value<0.05. Data are represented as mean ± SD. *, P<0.05