<div><p>Recently we identified multiple suramin-sensitivity genes with a genome wide screen in <i>Trypanosoma brucei</i> that includes the invariant surface glycoprotein ISG75, the adaptin-1 (AP-1) complex and two deubiquitylating enzymes (DUBs) orthologous to ScUbp15/HsHAUSP1 and pVHL-interacting DUB1 (type I), designated TbUsp7 and TbVdu1, respectively. Here we have examined the roles of these genes in trafficking of ISG75, which appears key to suramin uptake. We found that, while AP-1 does not influence ISG75 abundance, knockdown of TbUsp7 or TbVdu1 leads to reduced ISG75 abundance. Silencing TbVdu1 also reduced ISG65 abundance. TbVdu1 is a component of an evolutionarily conserved ubiquitylation switch and responsible for rapid receptor ...
The kinetoplastids are an important group of protozoa from the Excavata supergroup, and cause numero...
Variant surface glycoprotein (VSG) is central to antigenic variation in African trypanosomes. Althou...
ABSTRACT The critical virulence factor of bloodstream-form Trypanosoma brucei is the glycosylphospha...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
<p>A simplified schematic of the trypanosome endomembrane system is shown, with the flagellar pocket...
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of a...
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, in...
Control of protein levels is vital to cellular homeostasis, for maintaining a steady state, to coord...
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (...
African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect...
Supporting information for publication on modulation of surface Proteome through multiple ubiquityla...
The kinetoplastids are an important group of protozoa from the Excavata supergroup, and cause numero...
Variant surface glycoprotein (VSG) is central to antigenic variation in African trypanosomes. Althou...
ABSTRACT The critical virulence factor of bloodstream-form Trypanosoma brucei is the glycosylphospha...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma b...
<p>A simplified schematic of the trypanosome endomembrane system is shown, with the flagellar pocket...
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of a...
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, in...
Control of protein levels is vital to cellular homeostasis, for maintaining a steady state, to coord...
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (...
African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect...
Supporting information for publication on modulation of surface Proteome through multiple ubiquityla...
The kinetoplastids are an important group of protozoa from the Excavata supergroup, and cause numero...
Variant surface glycoprotein (VSG) is central to antigenic variation in African trypanosomes. Althou...
ABSTRACT The critical virulence factor of bloodstream-form Trypanosoma brucei is the glycosylphospha...