<p>This illustration depicts the current comprehensive knowledge of DNA methylation during human pre- and postimplantation development. The knowledge about DNA methylation during human preimplantation (left panel) is derived from [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005583#pgen.1005583.ref009" target="_blank">9</a>–<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005583#pgen.1005583.ref012" target="_blank">12</a>] whereas our study sheds light on postimplantation development (right panel).</p
There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known...
Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic develop...
Epigenetic marking systems confer stability of gene expression during mammalian development. Genome-...
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distrib...
<div><p>DNA methylation is globally reprogrammed during mammalian preimplantation development, which...
Early embryonic development is a very precise and complicated process. When a sperm meets an egg, a ...
<p><b>A,</b> Distribution of methylation levels of individual CpGs. The mean methylation levels of C...
After fertilization, the methylation status of the genome changes substantially when it undergoes ra...
Infants undergo extensive developments during their frst year of life. Although the biological mecha...
Summary: An adverse intrauterine environment is associated with long-term physiological changes in o...
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, ...
While DNA cytosine methylation is relatively stable in somatic tissues, it is highly dynamic during ...
Epigenetic marking systems confer stability of gene expression during mammalian development. Genome-...
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, ...
SummaryGlobal DNA demethylation in humans is a fundamental process that occurs in pre-implantation e...
There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known...
Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic develop...
Epigenetic marking systems confer stability of gene expression during mammalian development. Genome-...
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distrib...
<div><p>DNA methylation is globally reprogrammed during mammalian preimplantation development, which...
Early embryonic development is a very precise and complicated process. When a sperm meets an egg, a ...
<p><b>A,</b> Distribution of methylation levels of individual CpGs. The mean methylation levels of C...
After fertilization, the methylation status of the genome changes substantially when it undergoes ra...
Infants undergo extensive developments during their frst year of life. Although the biological mecha...
Summary: An adverse intrauterine environment is associated with long-term physiological changes in o...
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, ...
While DNA cytosine methylation is relatively stable in somatic tissues, it is highly dynamic during ...
Epigenetic marking systems confer stability of gene expression during mammalian development. Genome-...
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, ...
SummaryGlobal DNA demethylation in humans is a fundamental process that occurs in pre-implantation e...
There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known...
Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic develop...
Epigenetic marking systems confer stability of gene expression during mammalian development. Genome-...