Induction of cytokine/chemokine immune mediators in MAYV-infected subjects with or without persistent arthralgia.

<p>Serum samples were collected at the acute visit as well as the convalescent visit (20±10 days), at 90±10 days, at 180±15 days, and at 360±30 days after the acute visit. The serum concentrations of a variety of cytokines were assessed by a cytokine bead array. The cytokine concentrations in subjects with (open circles) or without (closed circles) persistent arthralgia were compared to healthy donor controls by a 2-tailed Mann-Whitney test. An asterisk (*) indicates statistical significance (p<0.05) when compared to healthy controls. Comparisons between MAYV infected groups were also performed by a 2-tailed Mann-Whitney test. No statistical significance (p<0.05) between the MAYV infected groups was found. The horizontal dotted line represents the median cytokine values for the healthy donor controls. Each circle corresponds to the cytokine concentration of an individual subject and the solid horizontal line represents the mean cytokine concentration of the group.