Kinetic profile of cytokines and chemokines significantly affected following MAYV infection.

<p>Serum samples were collected at the acute visit as well as the convalescent visit (20±10 days), at 90±10 days, at 180±15 days, and at 360±30 days after the acute visit. The serum concentrations of a variety of cytokines were assessed by a multiplex cytokine bead array. Three kinetic profiles are presented based on the peak of cytokine expression: <b>Acute:</b> cytokines/chemokines that peak during the acute phase (upon enrollment); <b>Convalescent:</b> cytokines/chemokines that peak during the convalescent phase 20 (±10) days post enrollment and may remain elevated for few months after MAYV infection; and <b>Sustained:</b> cytokines/chemokines whose expression remain elevated up to 12 months following MAYV infection. The box plot denotes the median, 25^th percentile, and 75^th percentile cytokine levels. The whiskers denote the minimum and maximum cytokine levels observed at each time point. The horizontal dotted line represents the median cytokine values for the healthy donor controls. Data sets were evaluated by using Wilcoxon non-parametric tests to evaluate the evolution of cytokine levels at each time point post-infection (*p<0.05).