Biacore assay results of binding affinity between recombinant human proteasome β1 subunit and fangchinoline or tetrandrine.

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

V. Troiano
K. Scarbaci
R. Ettari
N. Micale
C. Cerchia
A. Pinto
T. Schirmeister
E. Novellino
S. Grasso
A. Lavecchia
M. Zappal&#224

August 2014

A new series of pseudopeptide boronate proteasome inhibitors (2-3) was developed, through optimizati...

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S b5-subunit.Biochem

Christopher Blackburn
Kenneth M. Gigstad
Paul Hales
Khristofer Garcia
Matthew Jones
Frank J. Bruzzese
Cynthia Barrett
Jane X. Liu
Teresa A. Soucy
Darshan S. Sappal
Nancy Bump
Edward J. Olhava
Paul Fleming
Lawrence R. Dick
Christopher Tsu
Michael D. Sintchak
Jonathan L. Blank

January 2010

The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein...

A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

Verdoes, Martijn
Florea, Bogdan I.
Menendez-Benito, Victoria
Maynard, Christa J.
Witte, Martin D.
van der Linden, Wouter A.
van den Nieuwendijk, Adrianus M.C.H.
Hofmann, Tanja
Berkers, Celia R.
van Leeuwen, Fijs W.B.
Groothuis, Tom A.
Leeuwenburgh, Michiel A.
Ovaa, Huib
Neefjes, Jacques J.
Filippov, Dmitri V.
van der Marel, Gijs A.
Dantuma, Nico P.
Overkleeft, Herman S.

November 2006

SummaryThe proteasome is an essential evolutionary conserved protease involved in many regulatory sy...

Direct effects of fangchinoline and tetrandrine on recombinant human proteasome β1 subunit.

Dong Li (212687)
Yu Lu (11575)
Peng Sun (112156)
Li-Xing Feng (819890)
Miao Liu (148274)
Li-Hong Hu (552770)
Wan-Ying Wu (229665)
Bao-Hong Jiang (229672)
Min Yang (146229)
Xiao-Bo Qu (819891)
De-An Guo (229677)
Xuan Liu (49954)

October 2015

<p>(A) Chemical structure of fangchinoline. (B) Chemical structure of tetrandrine. (C) Real time bin...

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

Rut Wioletta
Poreba Marcin
Kasperkiewicz Paulina
Snipas J. Scott
Drag Marcin

January 2020

The proteasome is an enzyme complex critical for maintaining protein homeostasis. Perturbed proteaso...

Development of Methods to Screen and Evaluate Small Molecule Binders of the Proteasome

Maresh, Marianne Elizabeth

January 2021

The proteasome is responsible for the majority of protein degradation in the cell. Dysregulation of ...

Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells

Dong Li (212687)
Yu Lu (11575)
Peng Sun (112156)
Li-Xing Feng (819890)
Miao Liu (148274)
Li-Hong Hu (552770)
Wan-Ying Wu (229665)
Bao-Hong Jiang (229672)
Min Yang (146229)
Xiao-Bo Qu (819891)
De-An Guo (229677)
Xuan Liu (49954)

October 2015

<div><p>Fangchinoline is a bisbenzylisoquinoline alkaloid isolated from Radix <i>Stephaniae tetrandr...

Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells.

Dong Li
Yu Lu
Peng Sun
Li-Xing Feng
Miao Liu
Li-Hong Hu
Wan-Ying Wu
Bao-Hong Jiang
Min Yang
Xiao-Bo Qu
De-An Guo
Xuan Liu

Fangchinoline is a bisbenzylisoquinoline alkaloid isolated from Radix Stephaniae tetrandrae S. Moore...

Two-step Bioorthogonal Activity-Based Protein Profiling of Individual Human Proteasome Catalytic Sites

Overkleeft, H.S.
Xin, B.T.
Espinal, C.G.A.
Bruin, G. de
Filippov, D.V.
Marel, G.A. van der
Florea, B.I.

October 2019

Bioorthogonal chemistry allows the selective modification of biomolecules in complex biological samp...

RESEARCH ARTICLE Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer

Dong Li
Yu Lu
Peng Sun
Li-xing Feng
Miao Liu
Li-hong Hu
Bao-hong Jiang
Min Yang
Xiao-bo Qu
De-an Guo
Xuan Liu

August 2016

Fangchinoline is a bisbenzylisoquinoline alkaloid isolated fromRadix Stephaniae tetrandrae S. Moore....

Probing proteasome activity and function : cancer diagnostics and mechanism of antigen processing

Berkers, C.R.

October 2010

In cells, proteins are continuously synthesized and degraded to control protein levels and thereby r...

Chemical tools to monitor and control human proteasome activities

Bruin, G. de

June 2016

Proteasomes are multi-protein, multi-catalytic complexes responsible for the degradation of 80-90%...

Multicolor Monitoring of the Proteasome’s Catalytic Signature

Priestman, Melanie A.
Wang, Qunzhao
Jernigan, Finith E.
Chowdhury, Ruma
Schmidt, Marion
Lawrence, David S.

January 2015

The proteasome, a validated anticancer target, participates in an array of biochemical activities, w...

BIAcore: a microchip-based system for analyzing the formation of macromolecular complexes

Raghavan, Malini
Bjorkman, Pamela J.

April 1995

The formation of macromolecular complexes, for example the complex between an antibody and an antige...

A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits

Ventadour, Sophie
Jarzaguet, Marianne
Wing, Simon S.
Chambon, Christophe
Combaret, Lydie
Béchet, Daniel
Attaix, Didier
Taillandier, Daniel

January 2007

The 26 S proteasome is implicated in the control of many major biological functions but a reliable m...

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

V. Troiano
K. Scarbaci
R. Ettari
N. Micale
C. Cerchia
A. Pinto
T. Schirmeister
E. Novellino
S. Grasso
A. Lavecchia
M. Zappal&#224

August 2014

A new series of pseudopeptide boronate proteasome inhibitors (2-3) was developed, through optimizati...

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S b5-subunit.Biochem

Christopher Blackburn
Kenneth M. Gigstad
Paul Hales
Khristofer Garcia
Matthew Jones
Frank J. Bruzzese
Cynthia Barrett
Jane X. Liu
Teresa A. Soucy
Darshan S. Sappal
Nancy Bump
Edward J. Olhava
Paul Fleming
Lawrence R. Dick
Christopher Tsu
Michael D. Sintchak
Jonathan L. Blank

January 2010

The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein...

A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

Verdoes, Martijn
Florea, Bogdan I.
Menendez-Benito, Victoria
Maynard, Christa J.
Witte, Martin D.
van der Linden, Wouter A.
van den Nieuwendijk, Adrianus M.C.H.
Hofmann, Tanja
Berkers, Celia R.
van Leeuwen, Fijs W.B.
Groothuis, Tom A.
Leeuwenburgh, Michiel A.
Ovaa, Huib
Neefjes, Jacques J.
Filippov, Dmitri V.
van der Marel, Gijs A.
Dantuma, Nico P.
Overkleeft, Herman S.

November 2006

SummaryThe proteasome is an essential evolutionary conserved protease involved in many regulatory sy...

Direct effects of fangchinoline and tetrandrine on recombinant human proteasome β1 subunit.

Dong Li (212687)
Yu Lu (11575)
Peng Sun (112156)
Li-Xing Feng (819890)
Miao Liu (148274)
Li-Hong Hu (552770)
Wan-Ying Wu (229665)
Bao-Hong Jiang (229672)
Min Yang (146229)
Xiao-Bo Qu (819891)
De-An Guo (229677)
Xuan Liu (49954)

October 2015

<p>(A) Chemical structure of fangchinoline. (B) Chemical structure of tetrandrine. (C) Real time bin...

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

Rut Wioletta
Poreba Marcin
Kasperkiewicz Paulina
Snipas J. Scott
Drag Marcin

January 2020

The proteasome is an enzyme complex critical for maintaining protein homeostasis. Perturbed proteaso...

Development of Methods to Screen and Evaluate Small Molecule Binders of the Proteasome

Maresh, Marianne Elizabeth

January 2021

The proteasome is responsible for the majority of protein degradation in the cell. Dysregulation of ...

Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells

Dong Li (212687)
Yu Lu (11575)
Peng Sun (112156)
Li-Xing Feng (819890)
Miao Liu (148274)
Li-Hong Hu (552770)
Wan-Ying Wu (229665)
Bao-Hong Jiang (229672)
Min Yang (146229)
Xiao-Bo Qu (819891)
De-An Guo (229677)
Xuan Liu (49954)

October 2015

<div><p>Fangchinoline is a bisbenzylisoquinoline alkaloid isolated from Radix <i>Stephaniae tetrandr...

Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells.

Dong Li
Yu Lu
Peng Sun
Li-Xing Feng
Miao Liu
Li-Hong Hu
Wan-Ying Wu
Bao-Hong Jiang
Min Yang
Xiao-Bo Qu
De-An Guo
Xuan Liu

Fangchinoline is a bisbenzylisoquinoline alkaloid isolated from Radix Stephaniae tetrandrae S. Moore...

Two-step Bioorthogonal Activity-Based Protein Profiling of Individual Human Proteasome Catalytic Sites

Overkleeft, H.S.
Xin, B.T.
Espinal, C.G.A.
Bruin, G. de
Filippov, D.V.
Marel, G.A. van der
Florea, B.I.

October 2019

Bioorthogonal chemistry allows the selective modification of biomolecules in complex biological samp...

RESEARCH ARTICLE Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer

Dong Li
Yu Lu
Peng Sun
Li-xing Feng
Miao Liu
Li-hong Hu
Bao-hong Jiang
Min Yang
Xiao-bo Qu
De-an Guo
Xuan Liu

August 2016

Fangchinoline is a bisbenzylisoquinoline alkaloid isolated fromRadix Stephaniae tetrandrae S. Moore....

Probing proteasome activity and function : cancer diagnostics and mechanism of antigen processing

Berkers, C.R.

October 2010

In cells, proteins are continuously synthesized and degraded to control protein levels and thereby r...

Chemical tools to monitor and control human proteasome activities

Bruin, G. de

June 2016

Proteasomes are multi-protein, multi-catalytic complexes responsible for the degradation of 80-90%...

Multicolor Monitoring of the Proteasome’s Catalytic Signature

Priestman, Melanie A.
Wang, Qunzhao
Jernigan, Finith E.
Chowdhury, Ruma
Schmidt, Marion
Lawrence, David S.

January 2015

The proteasome, a validated anticancer target, participates in an array of biochemical activities, w...

BIAcore: a microchip-based system for analyzing the formation of macromolecular complexes

Raghavan, Malini
Bjorkman, Pamela J.

April 1995

The formation of macromolecular complexes, for example the complex between an antibody and an antige...

A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits

Ventadour, Sophie
Jarzaguet, Marianne
Wing, Simon S.
Chambon, Christophe
Combaret, Lydie
Béchet, Daniel
Attaix, Didier
Taillandier, Daniel

January 2007

The 26 S proteasome is implicated in the control of many major biological functions but a reliable m...

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

V. Troiano
K. Scarbaci
R. Ettari
N. Micale
C. Cerchia
A. Pinto
T. Schirmeister
E. Novellino
S. Grasso
A. Lavecchia
M. Zappal&#224

August 2014

A new series of pseudopeptide boronate proteasome inhibitors (2-3) was developed, through optimizati...

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S b5-subunit.Biochem

Christopher Blackburn
Kenneth M. Gigstad
Paul Hales
Khristofer Garcia
Matthew Jones
Frank J. Bruzzese
Cynthia Barrett
Jane X. Liu
Teresa A. Soucy
Darshan S. Sappal
Nancy Bump
Edward J. Olhava
Paul Fleming
Lawrence R. Dick
Christopher Tsu
Michael D. Sintchak
Jonathan L. Blank

January 2010

The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein...

A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

Verdoes, Martijn
Florea, Bogdan I.
Menendez-Benito, Victoria
Maynard, Christa J.
Witte, Martin D.
van der Linden, Wouter A.
van den Nieuwendijk, Adrianus M.C.H.
Hofmann, Tanja
Berkers, Celia R.
van Leeuwen, Fijs W.B.
Groothuis, Tom A.
Leeuwenburgh, Michiel A.
Ovaa, Huib
Neefjes, Jacques J.
Filippov, Dmitri V.
van der Marel, Gijs A.
Dantuma, Nico P.
Overkleeft, Herman S.

November 2006

SummaryThe proteasome is an essential evolutionary conserved protease involved in many regulatory sy...

Biacore assay results of binding affinity between recombinant human proteasome β1 subunit and fangchinoline or tetrandrine.

Abstract

Extracted data

Biacore assay results of binding affinity between recombinant human proteasome β1 subunit and fangchinoline or tetrandrine.

Abstract

Extracted data

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