Conserved OR sequences revealed by logo plot shared with M71 and mβ2AR.

<p>(A) OR logo using mouse Class I and II odorant receptor sequences. Most highly conserved OR residues are depicted with black circles. M71 and mβ2AR sequences are delineated underneath logo plot; Residues with greater than 50% bit conservation to OR logo are underlined. Conserved residues between M71 and mβ2AR are in bold and red. M71 residue swaps between M71 and mβ2AR are delineated in purple and green, respectively. M71 residues converted to alanine are described with bold blue A. Five conserved methionine residues, three conserved histidine residues and one weakly conserved tryptophan residue marked with asterisk. Two of these residues are also found in OSN expressed TAARs marked with red asterisk. (B) Schematic of OR seven transmembrane structure with conserved methionine and histidine residues depicted in linear and predicted 3 dimensional state. Methionine and histidine residues in non-transmembrane might be in close enough proximity to coordinate a metal group, like copper. Methionine residues in TM3 and TM7 may form bridge if modified.