One new 19-<i>nor</i> cucurbitane-type triterpenoid from the stems of <i>Momordica charantia</i>

<p>One new 19-<i>nor</i> cucurbitane-type triterpenoid (3<i>β</i>,9<i>β</i>,25-trihydroxy-7<i>β</i>-methoxy-19-nor-cucurbita-5,23(<i>E</i>)-diene) (<b>1</b>), together with other six known cucurbitane-type triterpenoids (<b>2–7</b>), were isolated from the stems of <i>Momordica charantia</i> L. The chemical structure of <b>1</b> was elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY and ROESY), MS experiments. Using MTT assay, compound <b>1</b> exhibited weak cytotoxicity against HL-60, A-549, and SK-BR-3 cell lines with the IC₅₀ values at 27.3, 32.7 and 26.6 μM, respectively.