<p>Reagents and conditions: a. TsOH, ethanol; 0°C, NaBH<sub>4</sub>; b. K<sub>2</sub>CO<sub>3</sub>, ethanol; c. Pd/C, H<sub>2</sub>, RT, 12 h; d. BBr<sub>3</sub>, CH<sub>2</sub>Cl<sub>2</sub>, -20°C, 2 h; RT, 4 h. e. Et<sub>3</sub>N, CH<sub>2</sub>Cl<sub>2</sub>; f. 180°C, neat, N<sub>2</sub>.</p
<p>Reagents and conditions: i) H2, Pd/C (10% w/w), THF, rt, 18 h; ii) BBr3, DCM, −78°C -rt, 2 h; iii...
Reagents and conditions: (a) 4-nitropyrazole, Cs2CO3, DMF, 77% (b) PPTS, acetone/H2O, 88%; (c) NaBH4...
<p>Reagents and conditions: a. NaBH<sub>4</sub>, MeOH; b. PBr<sub>3</sub>, pyridine, 0°C; c. P(OEt)<...
Reagents and conditions: a) for 2a-c: HCl·H2NO(CH2)nCOOH, acetic acid, 80 °C, 3h; for 2d: HCl·H2NO(C...
<p>Reagents and conditions: (a) conc. HCl, ZnCl<sub>2</sub>, HCHO(37% in H<sub>2</sub>O); (b) substi...
<p>Reagents and conditions: i) from <b>1</b> for <b>23</b>, from <b>5</b> for <b>24</b>, from <b>32<...
<p><i><sup>a</sup></i>Reagents and conditions: a) Tosylmethylisocyanate, Na<sub>2</sub>CO<sub>3</sub...
<p><i>Reagents and conditions</i>: (i) SOCl<sub>2</sub>, MeOH, r.t., 2.5 h, reflux 30 min, r.t. 4 h,...
<p>Synthesis of 14: Reagents and conditions: (a) 4-phenyl butyl bromide, K<sub>2</sub>CO<sub>3</sub>...
<p>Reagents and Conditions: i) EtOH, 40% NaOH, 0°C, stir, 30 min; rt, stir, 4 h; ii) EtOH, Phenylhyd...
<p><i>Reagent</i>s: <b>i</b>: NH<sub>2</sub>NH<sub>2</sub><sup>.</sup>H<sub>2</sub>O, EtOH, reflux, ...
<p>Reagents (i) CH<sub>3</sub>C(OEt)<sub>3</sub>, CH<sub>3</sub>COOH, 138°C; (ii) KOH, EtOH.</p
<p>Reagents and Conditions: (a) Ethyl 3-bromobutyrate, Cs<sub>2</sub>CO<sub>3</sub>, MeCN, reflux, 2...
Reagents and conditions: (a) 4-aminopyrazole hydrochloride, Et3N, DMF, 87%; (b) cyclohex-1-en-1-ylbo...
<p>Reagents and Conditions: (a) epichlorohydrin, Cs<sub>2</sub>CO<sub>3</sub>, MeCN, reflux, 4 h; (b...
<p>Reagents and conditions: i) H2, Pd/C (10% w/w), THF, rt, 18 h; ii) BBr3, DCM, −78°C -rt, 2 h; iii...
Reagents and conditions: (a) 4-nitropyrazole, Cs2CO3, DMF, 77% (b) PPTS, acetone/H2O, 88%; (c) NaBH4...
<p>Reagents and conditions: a. NaBH<sub>4</sub>, MeOH; b. PBr<sub>3</sub>, pyridine, 0°C; c. P(OEt)<...
Reagents and conditions: a) for 2a-c: HCl·H2NO(CH2)nCOOH, acetic acid, 80 °C, 3h; for 2d: HCl·H2NO(C...
<p>Reagents and conditions: (a) conc. HCl, ZnCl<sub>2</sub>, HCHO(37% in H<sub>2</sub>O); (b) substi...
<p>Reagents and conditions: i) from <b>1</b> for <b>23</b>, from <b>5</b> for <b>24</b>, from <b>32<...
<p><i><sup>a</sup></i>Reagents and conditions: a) Tosylmethylisocyanate, Na<sub>2</sub>CO<sub>3</sub...
<p><i>Reagents and conditions</i>: (i) SOCl<sub>2</sub>, MeOH, r.t., 2.5 h, reflux 30 min, r.t. 4 h,...
<p>Synthesis of 14: Reagents and conditions: (a) 4-phenyl butyl bromide, K<sub>2</sub>CO<sub>3</sub>...
<p>Reagents and Conditions: i) EtOH, 40% NaOH, 0°C, stir, 30 min; rt, stir, 4 h; ii) EtOH, Phenylhyd...
<p><i>Reagent</i>s: <b>i</b>: NH<sub>2</sub>NH<sub>2</sub><sup>.</sup>H<sub>2</sub>O, EtOH, reflux, ...
<p>Reagents (i) CH<sub>3</sub>C(OEt)<sub>3</sub>, CH<sub>3</sub>COOH, 138°C; (ii) KOH, EtOH.</p
<p>Reagents and Conditions: (a) Ethyl 3-bromobutyrate, Cs<sub>2</sub>CO<sub>3</sub>, MeCN, reflux, 2...
Reagents and conditions: (a) 4-aminopyrazole hydrochloride, Et3N, DMF, 87%; (b) cyclohex-1-en-1-ylbo...
<p>Reagents and Conditions: (a) epichlorohydrin, Cs<sub>2</sub>CO<sub>3</sub>, MeCN, reflux, 4 h; (b...
<p>Reagents and conditions: i) H2, Pd/C (10% w/w), THF, rt, 18 h; ii) BBr3, DCM, −78°C -rt, 2 h; iii...
Reagents and conditions: (a) 4-nitropyrazole, Cs2CO3, DMF, 77% (b) PPTS, acetone/H2O, 88%; (c) NaBH4...
<p>Reagents and conditions: a. NaBH<sub>4</sub>, MeOH; b. PBr<sub>3</sub>, pyridine, 0°C; c. P(OEt)<...