Synthesis of 4, 5, 8, 10, 14, and gigantol.
- Jie Wu (10038)
- Chuanjun Lu (820460)
- Xue Li (285380)
- Hua Fang (627909)
- Wencheng Wan (820461)
- Qiaohong Yang (820462)
- Xiaosheng Sun (820463)
- Meiling Wang (808623)
- Xiaohong Hu (308716)
- C.-Y. Oliver Chen (820464)
- Xiaoyong Wei (820465)
Publication date
October 2015
DOIAbstract
<p>Reagents and conditions: a. NaBH<sub>4</sub>, MeOH; b. PBr<sub>3</sub>, pyridine, 0°C; c. P(OEt)<sub>3</sub>, 120°C; d. different aldehydes, CH<sub>3</sub>ONa, 0°C to room temperature (RT), 12 h; e. Pd/C, H<sub>2</sub>, RT, 12 h; f. BBr<sub>3</sub>, CH<sub>2</sub>Cl<sub>2</sub>, -20°C, 2 h; RT, 4 h; g. NaH, ethanethiol, DMF, N<sub>2</sub>, reflux; h. MOMCl, <i>i</i>-Pr<sub>2</sub>NEt, CH<sub>2</sub>Cl<sub>2</sub>, 0°C, 1 h; RT, 12 h; i. diethyl naphthalen-1-ylmethylphosphonate, CH<sub>3</sub>ONa, 0°C, 1 h; rt, 12 h; j. 2 M HCl, methanol, 50°C, 1 h; k. BnBr, 18-crown-6, K<sub>2</sub>CO<sub>3</sub>, reflux, 9 h.</p
Add to ORKG